Lim 1992.
| Methods | Study design: randomized parallel groups Study dates: not stated | |
| Participants | Country: Singapore Sex: both Age: 18 ASA: I and II Procedure: removal of impacted or buried teeth Study size: 50 |
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| Interventions |
Randomized portion of anaesthetic: parts of TIVA vs parts of volatile agent Intervention 1: induction: (TIVA) propofol (2 mg/kg) at 40 mg/10 sec maintenance: propofol infusion reduced to 6 mg/kg/h by reducing flow manually 2 mg/kg/h every 10 minutes + propofol bolus (0.5 mg/kg) no narcotics as needed oxygen/air, N = 25 Intervention 2: induction: (thiopentone/isoflurane/N2O), thiopentone (4 mg/kg); maintenance: 66% N2O in oxygen + 0.5% isoflurane, N = 25 |
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| Outcomes | Primary outcomes: recovery characteristics Secondary outcome: awareness/wakefulness as defined using an awareness classification system (see Table 1): class 1 Comment: no awareness reported |
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| Notes |
Non‐randomized portion of anaesthetic: parts of TIVA vs parts of volatile agent N2O yes/narcotics/hypnotics bolus MCI/muscle relaxant induction yes/maintenance unclear
Induction: suxamethonium (1.0 mg to 1.5 mg/kg) + atracurium (0.5 mg/kg) + supplementary dose (0.1 mg/kg) Air/oxygen with TIVA and N2O with isoflurane Method of outcome determination: interview Bias survey sent to author |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Quote: "scheduled for surgical removal of impacted or buried teeth were randomly allocated to receive either TIVA using propofol" |
| Allocation concealment (selection bias) | Unclear risk | Comment: no information provided |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: anaesthesiologist: no information provided |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Quote: "The patients were interviewed by an anaesthetic trainee for complications of anaesthesia ..." |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: no missing outcome data |
| Selective reporting (reporting bias) | Low risk | Comment: awareness outcome part of inclusion criteria |
| Other bias | Unclear risk | Comment: insufficient information provided |