Zhou 2008.
| Methods | Study design: randomized parallel groups Study dates: NA |
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| Participants | Country: China Sex: female Age: mean age 39 ± 7 ASA: I‐II Procedure: gynaecologic laparoscopy Study size: 45 |
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| Interventions |
Randomized portion of anaesthetic: parts of TIVA (TCI propofol/propofol bolus) vs parts of volatile agent (sevoflurane) Intervention 1: induction and maintenance: sevoflurane 6%: induction; 4%: maintenance MAC, N = 15 Intervention 2: induction: TCI propofol 3 mg/mL, N = 15 Intervention 3: induction: propofol bolus 2 mg/kg, N = 15 |
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| Outcomes | Primary outcomes: BIS values and haemodynamics peri‐intubation Awareness/wakefulness as defined using an awareness classification system (see Table 1): class 1 Quote: "no adverse reaction concerning memory was observed in three groups" |
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| Notes |
Non‐randomized portion of anaesthetic: nitrous N/parts of TIVA vs volatile agent (sevoflurane) + narcotics (sufentanil) + muscle relaxant(s) (rocuronium) induction yes/maintenance unclear/ADM BIS 60 Induction: sufentanil 0.5 µg/kg + sevoflurane 6 MAC + rocuronium bromide 0.6 mg/kg/BIS Comment: intubation at BIS 60 is example of light anaesthesia Zancong Shen translator ROB survey sent yueyun@hotmail.com |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Quote survey: "Patients were randomized by their assigned random numbers, however after randomization each group was given different treatment drugs...And or anesthesia depth monitors like BIS (BIS is the key depth monitoring endpoint (60) when intubation was applied for all patients),Narcotrend, AAI, etc. All 45 patients had in GYN laparoscopy" |
| Allocation concealment (selection bias) | Unclear risk | Comment: no information provided |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: difficult to blind infusion‐based anaesthetic and volatile agent |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: assessor: no information provided |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: no missing data Quote: "They followed up with all patients post surgery for any adverse reaction related to memory, but did not find any)" |
| Selective reporting (reporting bias) | Low risk | Comment: awareness outcome part of inclusion criteria |
| Other bias | Unclear risk | Comment: insufficient information provided |