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. 2019 Mar 29;11(6):1874–1899. doi: 10.18632/aging.101882

Table 6. Pathway enrichment analysis results ('q-value (FDR: BH-method) less than 0.05').

Nº CpG Pathway Source Pathway Name P value Category Genes r2 Adj
15 KEGG Longevity regulating pathway 2.27E-26 All ADCY5, ADCY6, ADCY9, CAMK4, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, PRKAG2, RELA, RHEB, TSC1, ULK1 0
12 KEGG Longevity regulating pathway 3.23E-21 Cholesterol ADCY6, ADCY9, CAMK4, CREB5, FOXO1, IGF1R, MTOR, PRKAG2, RELA, RHEB, TSC1, ULK1 0.072
10 KEGG Longevity regulating pathway 8.67E-18 HOMA-Index ADCY5, ADCY6, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, RELA,ULK1 0.153
12 KEGG Longevity regulating pathway 3.23E-21 Waist Circumference ADCY5, ADCY6, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, PRKAG2, RELA, TSC1, ULK1 0.341
8 KEGG Longevity regulating pathway 2.30E-14 Metabolic Syndrome ADCY5, ADCY6, CREB5, IGF1R, INS, MTOR, RELA, ULK1 0.092

KEGG: Kyoto Encyclopedia of Genes and Genomes. HOMA: homeostatic model assessment BMI: Body mass index.