Table 6. Pathway enrichment analysis results ('q-value (FDR: BH-method) less than 0.05').

Nº CpG	Pathway Source	Pathway Name	P value	Category	Genes	r2 Adj
15	KEGG	Longevity regulating pathway	2.27E-26	All	ADCY5, ADCY6, ADCY9, CAMK4, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, PRKAG2, RELA, RHEB, TSC1, ULK1	0
12	KEGG	Longevity regulating pathway	3.23E-21	Cholesterol	ADCY6, ADCY9, CAMK4, CREB5, FOXO1, IGF1R, MTOR, PRKAG2, RELA, RHEB, TSC1, ULK1	0.072
10	KEGG	Longevity regulating pathway	8.67E-18	HOMA-Index	ADCY5, ADCY6, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, RELA,ULK1	0.153
12	KEGG	Longevity regulating pathway	3.23E-21	Waist Circumference	ADCY5, ADCY6, CREB5, FOXO1, IGF1, IGF1R, INS, MTOR, PRKAG2, RELA, TSC1, ULK1	0.341
8	KEGG	Longevity regulating pathway	2.30E-14	Metabolic Syndrome	ADCY5, ADCY6, CREB5, IGF1R, INS, MTOR, RELA, ULK1	0.092

KEGG: Kyoto Encyclopedia of Genes and Genomes. HOMA: homeostatic model assessment BMI: Body mass index.