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. 2019 Mar 26;11(6):1759–1777. doi: 10.18632/aging.101867

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Copyright © 2019 Choi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ribosome biosynthesis in GV, MII, and TubA-treated oocytes. (A) GSEA plots showing preferential downregulation of the KEGG ribosome in matched pairs of TubA20 treated (TubA/GV pairs) versus untreated control (MII/GV pairs). (B) Expression of ribosome biosynthesis-related functional genes in GV-, TubA-20 treated, and MII-stage oocytes. Y-axis shows the FPKM values of genes inferred from the transcriptome data. Right indicates a heatmap showing DEGs of Rps family genes in GV, MII, and TubA-treated oocytes. (C) IPA analysis of MII/GV and TubA/GV pairs. Shapes and lines are color-coded based on predicted associations and functions. Green and red indicate up- and downregulated gene expression.