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. 2019 Apr 5;10:324. doi: 10.3389/fneur.2019.00324

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Copyright © 2019 Liu, Chen, Qin, Gu, Chen, Zou, Jiang, Li, Bai, Zhang, Wang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The distribution of PC and WD in the whole brain. (A) The PC distribution in HC-low risk. (B) Significant effects of vascular burden on PC were observed in the DMN (such as bilateral superior frontal gyrus [SFG], inferior parietal lobule [IPL], and left posterior cingulate cortex [PCC], medial orbitofrontal cortex [mOFC]) and the ECN (such as bilateral inferior frontal gyrus [IFG] and right midcingulate cortex [MCC]) (P < 0.01, FDR corrected). (C) The WD distribution in HC-low risk. (D) The WD was significantly regulated in the regions of DMN (such as bilateral mOFC, middle temporal gyrus [MTG], and the right IPL) and the ECN (such as bilateral ACC, IFG, and anterior insula [AI]) (P < 0.01, FDR corrected). HC, healthy control; PC, participant coefficient; WD, within module degree.