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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: ACS Appl Mater Interfaces. 2018 Dec 14;10(51):44267–44278. doi: 10.1021/acsami.8b17264

Scheme 1. Schematic Diagram Showing the Formation Process of Capsule-Integrated PL/PG Multilayer Films for Multidrug Delivery Using LbL Self-Assembly Technologya.

Scheme 1.

aThe capsules impregnated with PL or PG polypeptides can function as vehicles for positively and negatively charged drug loading and release. (1) Self-assembly of (PL/PG)x multilayer nanofilms; (2) deposition of PG-impregnated CaCO3 particles (CaCO3PG); (3) self-assembly of PG/(PL/PG)y multilayer nanofilms; (4) deposition of PL-impregnated CaCO3 particles (CaCO3PL); (5) self-assembly of PG/(PL/PG)z multilayer nanofilms; (6) formation of capsule-integrated multilayer films by dissolving CaCO3 templates; and (7) pH-controlled drug loading and release.