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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: AAPS J. 2018 Apr 30;20(4):67. doi: 10.1208/s12248-018-0227-4

Figure 2.

Figure 2.

The top 50 exosomal miRNAs by number of reads are shown for HEK (A) and PC3 (B). Cellular versus exosomal read counts show high correlation for HEK (C) and PC3 (D), but a subset of miRNAs were enriched above four-fold in HEK cells (E) and PC3 cells (F). (G) Conversely, of the miRNAs found in both HEK and PC3 exosomes, a poor correlation in abundance was observed (R2=0.16). Abundant exosome miRNAs were considered to be present at >1% of the total mapped reads for all miRNAs. For HEK these 28 miRNAs represented 75% of all reads and for PC3 the 18 abundant miRNAs represented 80% of all reads. (H) Comparing the abundant miRNAs in HEK and PC3 exosomes demonstrated that some abundant miRNAs are shared between the HEK and PC3 cells (11), while others were unique to HEK (17) or PC3 (7) exosomes.