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. 2019 Apr 12;14(4):e0214816. doi: 10.1371/journal.pone.0214816

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© 2019 Neininger et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — A: Average SNP and indel density (1000G and GoNL data) around the TSS (±200 bp) of all RefSeq genes. The standard error of the mean is visualized for every datapoint. B: SNP pattern in direct vicinity (−15 to +12) of the TSS considering 1000G and GoNL data. Position 1 denotes the first intragenic nucleotide. C: Distribution of dinucleotides starting with cytosine in the flanking region of the TSS of all RefSeq genes. CpG and CpA dinucleotides are prevalent. D: Number of SNPs (1000G data) at individual dinucleotides. The majority of SNPs resides at CpG dinucleotides.