Table 2. Functional annotation of genes with a CpG at TSS position −1.

	Term	# Genes	% Genes	q–value
1.	Phosphoprotein	1110	52.0	3.5 ⋅ 10−13
2.	Acetylation	507	23.7	2.1 ⋅ 10−9
3.	Alternative splicing	1314	61.5	1.6 ⋅ 10−8
4.	Cytoplasm	658	30.8	2.7 ⋅ 10−8
5.	Nucleoplasm	412	19.3	7.2 ⋅ 10−7
6.	Protein binding	1134	53.1	2.6 ⋅ 10−6
7.	Protein transport	112	5.2	5.5 ⋅ 10−6
8.	Nucleus	668	31.3	8.3 ⋅ 10−5
9.	Vesicle–mediated transport	39	1.8	1.9 ⋅ 10−2
10.	Cytoskeleton	177	8.3	8.6 ⋅ 10−4
11.	Rab GTPase binding	34	1.6	1.0 ⋅ 10−2
12.	Endocytosis	52	2.4	4.1 ⋅ 10−3
13.	Cytosol	450	21.1	6.0 ⋅ 10−3
14.	Guanine–nucleotide releasing factor	35	1.6	2.1 ⋅ 10−3
15.	Cell cycle	106	5.0	3.0 ⋅ 10−3
16.	Mitochondrion	162	7.6	4.1 ⋅ 10−3
17.	Transport	271	12.7	1.4 ⋅ 10−2
18.	Cell division	68	3.2	1.5 ⋅ 10−2
19.	Electron transport	24	1.1	1.4 ⋅ 10−2

DAVID functional annotation [48] was applied to the 2,136 RefSeq genes with a CpG dinucleotide at TSS position −1. Duplicated terms from different databases were deleted and the one with smallest p-value was retained. Shown are terms with adjusted p–value of p < 0.05 (Benjamini-Hochberg correction).