In the present study, the animals were randomly divided into 5 groups (n=10) as follows: Group A, control: received vehicle (tap water) for 5 consecutive weeks and saline was injected intravenously (i.v.) on the 7th day of the experiment. Group B, ADR: received vehicle (tap water) for 5 consecutive weeks and ADR was injected (5 mg/kg, i.v) [15] on the 7th day of the experiment. Group C, P. major 600 + ADR: received P. major extract (600 mg/kg, in drinking water) [5] for 5 consecutive weeks and i.v. injection of ADR on the 7th day of the experiment. Group D, P. major 1200+ADR: received P. major extract (1200 mg/kg, in drinking water) [5] for 5 consecutive weeks and i.v. injection of ADR on the 7th day of the experiment. Group E, P. major 1200: received P. major extract (1200 mg/kg, in drinking water) and i.v. injection of saline on the 7th day of the experiment.