Table 3.
Summary of the immuno-modulatory effects of Portulaca oleracea.
| Type of extract or constituents | Study model | Result | Ref. |
|---|---|---|---|
| ethyl acetate and chloroform extracts of Portulaca werdermannii and Portulaca hirsutissima | BALB/c-isolatcd splenocytes | Inhibited the proliferation induced by concanavalin A in BALB/c-isolated splenocytes | 1 |
| PO hydro-ethanolic extract | PHA-stimulated human lymphocytes | Attenuated the percentage of cell proliferation, NO production and the levels of IL-4, IL10, and IFN-γ. Propagates the Th1/Th2 (IFN-γ/IL-4) and Treg/Th2 (IL-10/IL-4) balances. |
2 |
| polysaccharide complexes (PSCs) isolated from aerial parts of PO | Human white blood cells Peyer’s patch (PP) cells from the small intestine of mice | Stimulated CD4+, CD25+ cells. Activated phagocytes Enhanced IL-6 produced from white blood cells. Intestinal immuno-modulatory activities by interacting with immune cells in Peyer’s patch cells. | 36 |
| Purslane polysaccharides (PPs) | MNNG -induced gastric cancer in rats | Appended SOD, CAT, GSH-Px, IL-2, IL-4 and TNF-α levels. Raised the body weight, lymphocyte proliferation, WBC count and splenocytcs proliferation. |
45 |
| 70% hydro-ethanolic PO extract | Asthmatic rats | Attenuates the levels of total protein, PLA2, and IgE in BALF | 46 |
| Pumpkin/purslane seed mixture | Hyper-cholesterolemic rats | Mitigates the lipid parameters. Improves IgG and IgM levels. | 47 |
| PO ethyl acetate extract | Cyclophosphamide-induced immuno-suppression in mice | Elevated phagocytosis and higher proliferative response in splenic lymphocytes. | 48 |