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. Author manuscript; available in PMC: 2019 Oct 26.
Published in final edited form as: J Mol Biol. 2018 Jun 1;430(22):4456–4468. doi: 10.1016/j.jmb.2018.05.039

Figure 2. The Formation of an EcMutL Sliding Clamp Leads to an Oscillating EcMutSEcMutL Search Complex.

Figure 2.

(a) Representative kymographs and illustrations showing the different types (colored letters) of EcMutS-EcMutL complex dissociations. The frequency (%) of each dissociation type is shown (right, colored numbers). (b) Illustration of a possible 3D diffusion mechanism for forming an EcMutL sliding clamp. (c) An illustration of a segmented search by an oscillating EcMutS-EcMutL complex. EcMutS-EcMutL complex diffuses in continuous DNA contact (left) while free EcMutS and EcMutL clamps diffuse in intermittent DNA contact (right).