. Author manuscript; available in PMC: 2019 Oct 26.

Published in final edited form as: J Mol Biol. 2018 Jun 1;430(22):4456–4468. doi: 10.1016/j.jmb.2018.05.039

Table 1.

MMR Components Across Species

E.coli	S.cerevisae	Human	Function
EcMutS	ScMsh2-ScMsh6	HsMSH2-HsMSH6	base-base/small IDL¹ recognition; sliding clamp
	ScMsh2-ScMsh3	HsMSH2-HsMSH3	small IDL¹/large IDL¹ (12 nt) recognition; sliding clamp
EcMutL	ScMlh1-ScPms1	HsMLH1-HsPMS2	MSH-dependent sliding clamp; PCNA-activated endonuclease; MutH tether (E.coli)
EcMutH	-	-	Hemimethylated-GATC endonuclease
EcUvrD	-	-	3’→5’ Helicase
EcExol, EcExoVII, EcExoX	-	-	ssDNA-dependent 3’→5’ exonuclease
EcExoVII, EcRecJ	-	-	ssDNA-dependent 5’→3’ exonuclease
-	ScExol	HsEXOI	dsDNA-dependent 3’→5’ ssDNA exonuclease
Ecβ-Clamp	ScPCNA	HsPCNA	Replication processivity factor; Polymerase tether

Insertion-deletion loop type mismatch