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. Author manuscript; available in PMC: 2020 Feb 28.
Published in final edited form as: J Control Release. 2019 Jan 21;296:225–231. doi: 10.1016/j.jconrel.2019.01.025

Fig. 2.

Fig. 2.

Chloride efflux from cystic fibrosis (CF) human bronchial epithelial CFBE41o- cells after treatment with free and NLC-bound lumacaftor (Luma), ivacaftor (Iva) and their combination. A–Different concentrations of free non-bound drugs; B – Combination of free non-bound and encapsulated into NLC Luma and Iva drugs. The ordinate shows the relative fluorescence of MQAE dye. Fluorescence in untreated CF cells was set to 1 unit. Mean ± SD are shown. *P < .05 when compared with untreated CF cells. †P < .05 when compared with the combination of free drugs.