Table 3.
Hazard ratios (HRs)a and 95% confidence intervals for the association between MetS and breast cancer mortality by menopausal status
| Pre-menopausal | Post-menopausal | |||
|---|---|---|---|---|
| Overall | Overall | Normal BMI | Overweight/Obese | |
| N (Deaths)b | 3,693 (15) | 90,662 (592) | 41,652 (228) | 49,009 (364) |
| MetSδ | ||||
| Crude | NE | 2.24 (1.43, 3.51) | 1.45 (0.34, 6.15) | 1.66 (0.90, 3.08) |
| Adjusted § | NE | 2.07 (1.32, 3.25) | 0.91 (0.22, 3.66) | 1.15 (0.81, 1.64) |
| Components | ||||
| High WC | 1.34 (0.23, 7.80) | 1.45 (1.18, 1.78) | 1.19 (0.70, 2.01) | 1.32 (0.97, 1.79) |
| High cholesterol | 0.79 (0.27, 2.27) | 1.21 (1.03, 1.42) | 1.39 (1.05, 1.84) | 1.16 (0.94, 1.43) |
| High blood pressure | 2.44 (0.85, 7.03) | 1.28 (1.09, 1.51) | 1.18 (0.88, 1.58) | 1.21 (0.99, 1.49) |
| High fasting glucose | 1.42 (0.18, 11.09) | 1.40 (1.04, 1.89) | 1.38 (0.65, 2.94) | 1.19 (0.86, 1.66) |
| Number of MetS Components | ||||
| 0(Ref) | 1.00 | 1.00 | 1.00 | 1.00 |
| 1 | 0.75 (0.08, 7.48) | 1.49 (1.05, 2.12) | 1.72 (1.11, 2.67) | 1.02 (0.57, 1.83) |
| 2 | 1.21 (0.10, 13.93) | 2.05 (1.43, 2.94) | 1.96 (1.14, 3.38) | 1.45 (0.83, 2.53) |
| 3+ | NE | 2.09 (1.33, 3.28) | 1.39 (0.33, 5.89) | 1.42 (0.76, 2.64) |
a,§
Models are adjusted for age (crude model), plus BMI, region,race,physical activity,smoking, and marital status.
b
Death = number of breast cancer deaths; N=number of observations.
δ
The reference category was women without any components of MetS.
Abbreviation: MetS, metabolic syndrome; NE, not estimable; Ref, reference; WC, waist circumference.
Bold indicates statistically significant at α= 0.05.