Table 5.
Hazard ratios (HRs)a and 95% confidence intervals for the association between MetS and breast cancer mortality by breast cancer subtype γ
| ER+/PR+ | ER+/PR− | ER−/PR− | |
|---|---|---|---|
| N (Deaths)b | 2,995 (169) | 587 (58) | 619 (89) |
| MetSδ | |||
| Crude | 1.87 (0.78, 4.49) | 3.10 (0.63, 15.43) | 0.62 (0.17, 2.30) |
| Adjusted§ | 1.28 (0.52, 3.16) | 1.89 (0.36,10.05) | 0.44 (0.11, 1.75) |
| Components | |||
| High WC | 1.15 (0.72, 1.84) | 1.11 (0.52, 2.33) | 1.21 (0.58, 2.55) |
| High Cholesterol | 1.21 (0.90, 1.66) | 1.53 (0.89, 2.63) | 1.02 (0.66, 1.56) |
| High blood pressure | 1.16 (0.85, 1.60) | 1.25 (0.73, 2.14) | 1.09 (0.70, 1.70) |
| High fasting glucose | 1.72 (1.00, 2.96) | 0.80 (0.24, 2.64) | 1.70 (0.84, 3.46) |
| Number of MetS Components | |||
| 0(Ref) | 1.00 | 1.00 | 1.00 |
| 1 | 1.18 (0.59, 2.35) | 1.86 (0.54, 6.40) | 0.66 (0.30, 1.45) |
| 2 | 1.91 (0.94, 3.88) | 2.39 (0.65, 8.72) | 0.97 (0.42, 2.25) |
| 3+ | 1.23 (0.47, 3.22) | 2.05 (0.38, 10.96) | 0.50 (0.13, 2.03) |
Crude model included MetS and age only.
a,§
Models were adjusted for age, race, BMI, education, region, physical activity, smoking, and marital status
b
Death, number of those who died of breast cancer; N=sample size
δ
The reference category was women without any components of MetS.
γ
ER and PR status only due to limited sample sizes on HER2 receptor status
Abbreviations: ER, estrogen receptor; MetS, metabolic syndrome; PR, progesterone receptor; Ref, reference; WC, waist circumference.
Bold indicates a statistically significant value.