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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Cell Rep. 2019 Apr 2;27(1):154–171.e9. doi: 10.1016/j.celrep.2019.03.007

Figure 1. Establishing an Experimental-Mathematical Modeling Framework for Understanding a Complete HIV Transcriptional Circuit.

Figure 1.

(A) Simplistic scheme of HIV proviral fate after infection and integration into the host cell genome. Latent viruses can be reactivated in response to immune stimulation.

(B) Scheme depicting the latent proviral state and its associated transcriptional circuit (basal) and output.

(C) Scheme depicting the active proviral state and its associated transcriptional circuit (host) and output.

(D) Scheme depicting the super-active proviral state and its associated transcriptional circuit (viral) and output.

(E) Scheme of an incomplete HIV transcriptional circuit.

(F) Scheme of a complete HIV transcriptional circuit.