Table 3.
Pearson’s correlations (P-value) of urine metabolites with clinical variables in the study population
| Urine metabolites | Age | Diabetes duration | Systolic blood pressure | BMI | HbA1c | ACR | GFR |
|---|---|---|---|---|---|---|---|
| 2-ethyl 3-OH propionate | −0.20 (0.124) | 0.03 (0.822) | −0.27 (0.034) | −0.11 (0.389) | 0.56 (< 0.001) | −0.04 (0.745) | 0.45 (< 0.001) |
| 3-hydroxy propionate | −0.35 (0.006) | −0.11 (0.390) | − 0.27 (0.033) | −0.12 (0.337) | 0.43 (0.001) | − 0.17 (0.191) | 0.46 (< 0.001) |
| 3-hydroxy isovalerate | −0.37 (0.003) | −0.13 (0.324) | − 0.21 (0.106) | − 0.12 (0.349) | 0.47 (< 0.001) | − 0.11 (0.381) | 0.55 (< 0.001) |
| 3-methyl-crotonyl Glycine | −0.14 (0.262) | 0.05 (0.704) | − 0.09 (0.478) | −0.04 (0.762) | 0.30 (0.016) | 0.004 (0.977) | 0.24 (0.060) |
| 3-hydroxy isobu-tyrate | −0.16 (0.201) | 0.02 (0.899) | −0.14 (0.286) | − 0.01 (0.950) | 0.52 (< 0.001) | −0.08 (0.526) | 0.41 (0.001) |
| Tiglyglycine | −0.10 (0.443) | 0.01 (0.954) | −0.24 (0.061) | − 0.21 (0.095) | 0.25 (0.050) | −0.04 (0.729) | 0.12 (0.351) |
| Aconitic acid | −0.18 (0.160) | 0.01 (0.931) | − 0.34 (0.007) | − 0.26 (0.041) | 0.47 (< 0.001) | − 0.24 (0.062) | 0.42 (0.001) |
| Citric acid | − 0.05 (0.686) | − 0.03 (0.789) | −0.35 (0.006) | −0.11 (0.385) | 0.44 (< 0.001) | − 0.33 (0.009) | 0.32 (0.010) |
| Glycolic acid | − 0.34 (0.007) | −0.20 (0.114) | − 0.30 (0.016) | −0.09 (0.479) | 0.30 (0.017) | − 0.32 (0.010) | 0.42 (0.001) |
| Homovanillic acid | −0.15 (0.249) | − 0.03 (0.789) | −0.17 (0.193) | −0.06 (0.671) | 0.07 (0.580) | − 0.15 (0.244) | 0.02 (0.858) |
| Uracil | −0.07 (0.586) | 0.11 (0.401) | − 0.19 (0.131) | 0.25 (0.055) | 0.11 (0.389) | − 0.29 (0.024) | 0.17 (0.187) |
| 3-methyl adipic acid | − 0.12 (0.368) | −0.20 (0.126) | −0.29 (0.025) | −0.14 (0.288) | 0.22 (0.084) | − 0.14 (0.269) | 0.06 (0.636) |
P values < 0.05 are shown in boldface
ACR urine albumin/creatinine ratio, BMI body mass index, GFR glomerular filtration rate