Table 4.
Pearson’s correlations (P-values) of urine metabolites with glomerular structural parameters in 62 participants with type 2 diabetes mellitus
| VG | Sv | %FE | Podo | TFS | GBM | VvMes | VvInt | FPW | |
|---|---|---|---|---|---|---|---|---|---|
| 2-ethyl 3-OH pro-pionate | −0.04 (0.765) | 0.21 (0.095) | 0.21 (0.105) | 0.17 (0.196) | 0.16 (0.202) | 0.02 (0.863) | −0.11 (0.384) | −0.10 (0.430) | −0.06 (0.667) |
| 3-hydroxy propionate | −0.04 (0.745) | 0.21 (0.101) | 0.15 (0.249) | 0.17 (0.188) | 0.19 (0.143) | 0.06 (0.641) | −0.14(0.267) | −0.24 (0.061) | −0.02 (0.865) |
| 3-hydroxy isovalerate | 0.03 (0.831) | 0.19 (0.135) | 0.06 (0.640) | 0.25 (0.050) | 0.21 (0.105) | −0.04 (0.764) | −0.19 (0.149) | −0.23 (0.069) | −0.06 (0.635) |
| 3-methyl-crotonyl glycine | 0.15 (0.238) | 0.04 (0.770) | −0.16 (0.202) | 0.02 (0.886) | 0.16 (0.204) | 0.17 (0.193) | 0.17 (0.177) | −0.03 (0.797) | 0.07 (0.596) |
| 3-hydroxy isobutyrate | 0.08 (0.538) | 0.22 (0.092) | 0.14 (0.295) | 0.19 (0.151) | 0.24 (0.066) | 0.04 (0.777) | −0.10 (0.462) | −0.15 (0.248) | −0.01 (0.929) |
| Tiglyglycine | −0.01 (0.935) | 0.05 (0.685) | 0.02 (0.875) | −0.03 (0.840) | 0.08 (0.546) | 0.12 (0.346) | 0.15 (0.254) | 0.11 (0.396) | −0.02 (0.879) |
| Aconitic acid | −0.11 (0.386) | 0.30 (0.017) | 0.18 (0.162) | 0.06 (0.628) | 0.24 (0.059) | 0.01 (0.942) | −0.17 (0.193) | −0.20 (0.111) | −0.11 (0.385) |
| Citric acid | −0.18 (0.165) | 0.47 (< 0.001) | 0.25 (0.053) | 0.16 (0.219) | 0.31 (0.014) | −0.14 (0.290) | −0.30 (0.020) | −0.18 (0.168) | −0.03 (0.811) |
| Glycolic acid | −0.10 (0.453) | 0.25 (0.053) | 0.14 (0.285) | 0.17 (0.181) | 0.20 (0.129) | −0.03 (0.806) | −0.24 (0.056) | −0.27 (0.036) | −0.13 (0.310) |
| Homovanillic acid | −0.10 (0.454) | 0.18 (0.162) | 0.08 (0.540) | −0.03 (0.794) | 0.11 (0.382) | −0.05 (0.693) | −0.07 (0.614) | −0.10 (0.455) | −0.33 (0.008) |
| Uracil | −0.15 (0.242) | 0.15 (0.264) | 0.11 (0.410) | −0.09 (0.469) | 0.06 (0.653) | −0.03 (0.798) | −0.21 (0.100) | −0.10 (0.426) | −0.10 (0.424) |
| 3-methyl adipic acid | 0.03 (0.819) | −0.04 (0.778) | −0.14 (0.283) | −0.08 (0.531) | 0.09 (0.494) | 0.21 (0.105) | 0.12 (0.336) | −0.08 (0.535) | −0.08 (0.560) |
P values < 0.05 are shown in boldface
VG glomerular volume, Sv glomerular filtration surface density, %FE percentage of fenestrated endothelium, Podo podocyte cell number per glomerulus, TFS total filtration surface per glomerulus, GBM glomerular basement membrane width, VvMes mesangial fractional volume, VvInt cortical interstitial fractional volume, FPW foot process width