Table 5.
Partial Pearson’s correlation matrix (P-values) between urine metabolite concentrations and morphometric variables
| VG | Sv | %FE | Podo | TFS | GBM | VvMes | VvInt | FPW | |
|---|---|---|---|---|---|---|---|---|---|
| 2-ethyl 3-OH propionate | 0.02 (0.884) | 0.22 (0.109) | 0.32 (0.019) | 0.22 (0.102) | 0.19 (0.174) | −0.15 (0.259) | −0.25 (0.067) | −0.08 (0.581) | −0.17 (0.202) |
| 3-hydroxy propionate | 0.04 (0.776) | 0.14 (0.299) | 0.16 (0.249) | 0.15 (0.260) | 0.18 (0.190) | −0.03 (0.837) | −0.15 (0.288) | −0.18 (0.187) | −0.06 (0.656) |
| 3-hydroxy isovalerate | 0.04 (0.768) | 0.15 (0.282) | 0.07 (0.626) | 0.24 (0.072) | 0.15 (0.271) | −0.20 (0.149) | −0.24 (0.084) | −0.17 (0.204) | −0.14 (0.317) |
| 3-methyl-crotonyl glycine | 0.15 (0.262) | 0.05 (0.735) | −0.16 (0.254) | 0.01 (0.916) | 0.16 (0.242) | 0.10 (0.457) | 0.15 (0.286) | 0.01 (0.931) | 0.05 (0.697) |
| 3− hydroxy isobutyrate | 0.13 (0.354) | 0.21 (0.119) | 0.21 (0.126) | 0.22 (0.107) | 0.25 (0.069) | −0.09 (0.505) | −0.19 (0.169) | −0.18 (0.201) | −0.12 (0.391) |
| Tiglyglycine | 0.04 (0.761) | 0.01 (0.949) | 0.02 (0.878) | −0.02 (0.876) | 0.08 (0.546) | 0.08 (0.541) | 0.15 (0.278) | 0.22 (0.105) | 0.01 (0.940) |
| Aconitic acid | −0.02 (0.909) | 0.29 (0.030) | 0.19 (0.155) | 0.05 (0.713) | 0.32 (0.019) | −0.09 (0.528) | −0.22 (0.113) | −0.21 (0.125) | −0.23 (0.095) |
| Citric acid | −0.07 (0.627) | 0.50 (< 0.001) | 0.25 (0.062) | 0.18 (0.179) | 0.43 (0.001) | −0.25 (0.066) | − 0.36 (0.007) | −0.21 (0.117) | −0.12 (0.394) |
| Glycolic acid | −0.05 (0.708) | 0.15 (0.290) | 0.10 (0.458) | 0.12 (0.386) | 0.13 (0.340) | −0.09 (0.509) | −0.22 (0.104) | −0.17 (0.206) | −0.14 (0.300) |
| Homovanillic acid | −0.004 (0.980) | 0.15 (0.288) | 0.05 (0.693) | −0.03 (0.846) | 0.17 (0.216) | − 0.07 (0.628) | −0.05 (0.706) | 0.03 (0.826) | − 0.31 (0.022) |
| Uracil | − 0.09 (0.500) | 0.07 (0.597) | 0.06 (0.648) | −0.12 (0.369) | 0.04 (0.754) | − 0.04 (0.794) | − 0.24 (0.075) | −0.07 (0.640) | −0.11 (0.440) |
| 3-methyl adipic acid | 0.16 (0.249) | −0.18 (0.176) | − 0.23 (0.092) | −0.13 (0.345) | 0.06 (0.658) | 0.22 (0.113) | 0.19 (0.172) | −0.01 (0.928) | −0.03 (0.805) |
P values < 0.05 are shown in boldface
Correlations are adjusted for age, sex, diabetes duration, hemoglobin A1c, mean arterial pressure, GFR, and treatment assignment
VG glomerular volume, SV glomerular filtration surface density, %FE percentage of fenestrated endothelium, Podo podocyte cell number per glomerulus, TFS total filtration surface per glomerulus, GBM glomerular basement membrane width, VvMes mesangial fractional volume, VvInt cortical interstitial fractional volume, FPW foot process width