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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Hepatology. 2019 Mar 18;69(5):1931–1945. doi: 10.1002/hep.30487

Figure 3. ARID1A bound promoter sequences of many lipid homeostasis genes and regulated their expression.

Figure 3.

A. Representative gene sets affected in LKO mice without HFD stimulation. Several pathways relating to lipid handling are significantly affected.

B. qPCR for genes in pathways related to lipid handling. 11 of the 23 genes show significantly altered expression levels in LKO livers (n = 9), including cholesterol synthesis and inflammation,

C. Lipogenesis (with associated Western blotting),

D. Fatty acid oxidation,

E. And lipid handling and gluconeogenesis (with associated Western blotting).

F. Representative ChIP-seq data showing Arid1a binding peaks at promoter sequences of genes seen to be differentially expressed in LKO livers. These peaks coincide with H3K4me3, H3K27ac, and C/ebpα binding peaks at the same location.