Table 1.
Specific components of ADNI classification criteria to distinguish CN, Early MCI, Late MCI, and AD.
| CN | Early MCI | Late MCI | AD | |
|---|---|---|---|---|
| Subjective complaint | None, aside from those common to other normal subjects of that age range. | Yes, by subject (verified by study partner) or study partner or clinician | Yes, by subject (verified by study partner) or study partner or clinician | Yes, by subject (verified by study partner) or study partner or clinician |
| MMSE* | ≥24 | ≥24 | ≥24 | 20-26 (Inclusive) |
| Logical Memory | ≥9 for 16+ years of education | 9-11 for 16+ years of education | ≤8 for 16+ years of education | ≤8 for 16+ years of education |
| ≥5 for 8-15 years of education | 5-9 for 8-15 years of education | ≤4 for 8-15 years of education | ≤4 for 8-15 years of education | |
| ≥3 for 0-7 years of Education | 3-6 for 0-7 years of education | ≤2 for 0-7 years of education | ≤2 for 0-7 years of education | |
| CDR | CDR=0 | CDR=0.5 | CDR=0.5 | CDR=0.5 or 1.0 |
| Memory Box score must be 0 | Memory Box score of at least 0.5 | Memory Box score of at least 0.5 | ||
| General cognition and functional status | Cognitively normal, based on an absence of significant impairment in cognitive functions or activities of daily living. | General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer’s disease cannot be made. | General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer’s disease cannot be made. | NINCDS/ADRDA criteria for probable AD |
Note. CN=Cognitively Normal; MCI=Mild Cognitive Impairment; AD=Alzheimer’s Disease; MMSE=Mini Mental State Exam; CDR=Clinical Dementia Rating; NINCDS/ADRDA=National Institute of Neurological and Communication Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association.
MMSE exceptions may be made for subjects with less than 8 years of education at the discretion of the project director. Logical Memory (LM) impairment was based on education-adjusted cutoffs on one paragraph of the Logical Memory II subscale of the Wechsler Memory Scale—Revised (maximum score of 25). Late MCI criteria were the only MCI criteria for ADNI 1 phase; Early MCI criteria were only included in ADNI GO and ADNI 2 phases. This table was adapted from the procedure manuals for ADNI 1, ADNI GO, and ADNI 2 available at http://adni.loni.usc.edu/methods/documents/.