Table 2.
Baseline demographic and clinical characteristics [mean (SD) or %] by group.
| CN (N=420) |
MCI (N=788) |
p-value | |
|---|---|---|---|
| Age | 74.70 (5.76) | 73.18 (7.54) | <.001 |
| Education | 16.34 (2.67) | 15.99 (2.81) | .036 |
| Female, % | 48.9% | 40.8% | .007 |
| GDS | 0.76 (1.08) | 1.68 (1.43) | <.001 |
| MMSE | 29.07 (1.14) | 27.61 (1.80) | <.001 |
| CDR=0.5, % | 0.5% | 99.7% | <.001 |
| CDR Memory=0.5, % | 0.6% | 96.9% | <.001 |
| FAQ | 0.22 (0.94) | 3.14 (4.06) | <.001 |
| Logical Memory II (raw) | 13.16 (3.30) | 5.68 (3.42) | <.001 |
| AVLT delayed recall (raw) | 7.56 (3.89) | 3.90 (3.86) | <.001 |
| Aβ | 1352.57 (659.56) | 1013.88 (553.69) | <.001 |
| p-tau/Aβ | 0.02 (0.02) | 0.04 (0.03) | <.001 |
| t-tau/Aβ | 0.23 (0.18) | 0.36 (0.27) | <.001 |
| p-tau | 21.70 (8.91) | 27.81 (14.19) | <.001 |
| t-tau | 236.39 (87.09) | 287.19 (126.30) | <.001 |
| APOE ε4+, % | 27.6% | 51.1% | <.001 |
Note. CN=Cognitively Normal; MCI=Mild Cognitive Impairment; GDS=Geriatric Depression Scale; MMSE=Mini-Mental State Exam; CDR=Clinical Dementia Rating; FAQ=Functional Activities Questionnaire; AVLT=Rey Auditory Verbal Learning Test; Aβ= β-amyloid; p-tau=hyperphosphorylated tau; t-tau=total tau APOE=Apolipoprotein E. For the CSF markers, the CN group had n=289 and MCI group had n=581.