Fig. 6.

Application of the mass conservation model to the experimental ELISA Aβ association with BV2 cells data. (a) Normalized concentration of Aβ in cells, $C_i^{\ast }$, from Fig. 4B were plotted against time and fit with a mathematical model, $C_i^{\ast }=\frac{k_{\mathit{up}}}{k_d}(1-\mathit{exp}(-k_d\cdot t\left)\right)$, to yield the ratio of the oAβ uptake rate constant to the Aβ depletion rate constant (k_up/k_d) for different doses of MAFP. (b) The ratio of the oAβ uptake rate constant to Aβ depletion rate constant (k_up/k_d) linearly decreased with increasing dose of MAFP. Data are represented as the mean ± SEM.