Table 2.
Effects of the intervention in APOE ε4 noncarriers and APOE ε4 carriers
| Mean (SEM) |
APOE ε4 noncarriers |
APOE ε4 carriers |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline |
Follow-up |
Baseline |
Follow-up |
||||||||||
| Controls | Exercise | P value∗ | Controls | Exercise | P value† | Controls | Exercise | P value∗ | Controls | Exercise | P value† | P value‡ | |
| Symbol Digit Modalities Test, # in 90 min | 25.78 (2.84) | 27.84 (2.50) | 0.0770 | 26.05 (3.35) | 24.49 (2.84) | 0.1637 | 25.58 (1.78) | 26.51 (2.84) | 0.9446 | 18.24 (3.97) | 25.55 (2.10) | 0.0598 | 0.0236 |
| Neuropsychiatric Inventory, range 0–144 | 10.81 (2.27) | 10.66 (2.02) | 0.6413 | 11.49 (2.40) | 10.10 (1.54) | 0.7331 | 9.03 (1.10) | 9.67 (1.19) | 0.4722 | 11.96 (1.45) | 7.80 (1.03) | 0.0002 | 0.1633 |
| Time-Up-and-Go, sec. | 6.67 (0.37) | 6.61 (0.34) | 0.3491 | 6.44 (0.31) | 6.76 (0.38) | 0.1794 | 6.58 (0.19) | 6.80 (0.19) | 0.2247 | 6.66 (0.34) | 6.40 (0.16) | 0.0153 | 0.0143 |
| Estimated VO2max, ml/kg/min | 24.99 (1.51) | 27.55 (1.43) | 0.1502 | 25.06 (1.31) | 33.21 (1.54) | 0.0240 | 26.57 (1.28) | 24.30 (0.91) | 0.0541 | 26.89 (1.22) | 28.60 (0.98) | 0.0002 | 0.8830 |
| 400 m walk, sec | 302.19 (17.11) | 302.80 (17.72) | 0.5428 | 298.48 (15.34) | 305.06 (18.19) | 0.5381 | 305.23 (8.11) | 307.53 (10.00) | 0.6896 | 307.63 (9.50) | 293.04 (7.18) | 0.0425 | 0.0681 |
| 10 m walk, m/sec | 1.39 (0.05) | 1.38 (0.03) | 0.9814 | 1.35 (0.04) | 1.34 (0.04) | 0.7779 | 1.39 (0.04) | 1.29 (0.02) | 0.0061 | 1.37 (0.03) | 1.34 (0.02) | 0.0269 | 0.1275 |
Bold values denote statistical significance P < 0.05.
∗
Baseline difference between controls versus exercise within APOE status. Adjusted for clustering within training groups and centers.
†
Follow-up difference between controls versus exercise (beyond the difference present at the baseline) within APOE status. Adjusted for clustering within training groups and centers.
‡
Effect of APOE status on the effect of exercise.