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. 2019 Apr 12;9:5964. doi: 10.1038/s41598-019-42375-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IgG1 levels in ApoE^−/− mice immunized with collagen α1α2(IV)-PADRE do not influence atherosclerotic plaque size, macrophage or SMC content. Levels of IgG1 against collagen α1α2(IV) peptides in ApoE^−/− mice immunized with α1α2(IV)-PADRE were divided in above and below median and analzyed for percentage of plaque in total aorta (A), aortic arch (B), descending aorta (C), subvalvular plaque area (D), CD68 (E) and smooth muscle cell alpha actin (D). Groups were compared using ANOVA or Kruskal-Wallis test. Each dot represents one mouse and the bar denotes mean or median values.