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. 2019 Apr 12;9:5964. doi: 10.1038/s41598-019-42375-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunization of ApoE^−/− mice with collagen α1α2(IV)-PADRE does not affect endothelial growth factors. HFG (A), VEGF-B (B) and VEGF-D (C) were measured in plasma from ApoE^−/− mice immunized with collagen α1α2(IV)-PADRE or PADRE by multiplex technology. Mann-Whitney test or t-test was used with bars showing median or mean value, respectively. Each dot represents one mouse.