Table 2.
Ingenuity Pathway Analysis results.
| Pathways | p-value – range |
|---|---|
| Th1 and Th2 Activation Pathway | 1.65E-25 |
| Th2 Pathway | 1.10E-20 |
| Th1 Pathway | 1.11E-20 |
| iCOS-iCOSL Signaling in T Helper Cells | 5.45E-117 |
| Altered T Cell and B Cell Signaling | 608E-16 |
| Physiologic Function | |
| Hematological System Development and Function | 6.19E-14–1.80E-73 |
| Tissue Morphology | 6.04E-14–1.80E-73 |
| Lymphoid Tissue Structure and Development | 6.08E-14–1.85E-72 |
| Immune Cell Trafficking | 6.19E-14–9.05E-67 |
| Hematopoiesis | 6.08E-14–7.80E-63 |
| Top Diseases and Biological Functions | |
| Cancer | 5.72E-14–6.44E-71 |
| Organismal Injury and Abnormalities | 6.04E-14–6.44E-71 |
| Inflammatory Response | 2.58E-14–9.05E-67 |
| Dermatological Diseases and Conditions | 2.46E-14–1.75E-65 |
| Gastrointestinal Disease | 5.38E-15–2.27E-49 |
Top five over-represented biological pathways and functions from a comparison of differential gene expression (N = 2992 DETs) between cluster 1 (mostly fast responders) and cluster 2 (mostly slow responders) in right colonic tissue from children with ASD and slow response versus fast response constipation.