Table 1.

Significance of association with hand preference measures in the UK Biobank, for SNPs and genes previously implicated in the literature.

Gene	CHR	Start	End	SNP	p-genEa	P-SNP lefta	p-SNP rightb	P-SNP ambic	Ref
LRRTM1	2	80515483	80531874	rs1007371	0.42	0.81	0.74	0.80	31
PCSK6	15	101840818	102065405	rs7182874	0.22	0.97	0.90	0.69	43
COMT	22	19929130	19957498	rs4680	0.78	0.95	0.89	0.64	36
SETDB2	13	50018429	50069138	rs4942830	0.52	0.45	0.94	0.11	39
SCN11A	3	38887260	38992052	rs883565	0.80	0.14	0.09	0.47	25
AK3	9	4711155	4742043	rs296859	0.77	0.98	0.92	0.76	25
AR	X	66764465	66950461	micro-satellitesd	0.76	—	—	—	33

Notes: Gene-level association is shown for the left-handed versus non-left-handed phenotype, and SNP level association for all three hand preference contrasts. START and END are according to the reference genome build 37 (see methods). P values are not adjusted for multiple testing, as they are all anyway greater than 0.05. ^aUsing GWAS of left-handed vs non-left-handed. ^bUsing GWAS of right-handed vs non-right-handed. ^cUsing GWAS of ambidextrous vs non-ambidextrous. ^dThe original study made use of a microsatellite repeat polymorphism which was not genotyped or imputed in the UK Biobank dataset.