Table 2.
Summary of patient characteristics, MR imaging and volumetric parameters for the groups of patients considered in the study.
| Discovery cohort | Validation cohort | ||
|---|---|---|---|
| Patient characteristics | Number of patients (censored) | 311 (27) | 93 (12) |
| Age (years) median (range) | 63 (19–86) | 62 (14–86) | |
| Sex {male (M), Female (F)} | 44% F; 56% M | 47% F; 53% M | |
| Survival (months) median (range) | 12.76 (0.13–82.97) | 11.77 (0.72–59.20) | |
| Type of resection (total, subtotal or biopsy) | 149 Total (47.91%) | 17 Total (18.28%) | |
| 113 Subtotal (36.33%) | — | ||
| 49 Biopsy (15.76%) | 8 Biopsy (8.60%) | ||
| — | 68 Unknown (73.12%) | ||
| Type of treatment (Chemotherapy (CT) and Radiotherapy (RT)) | 241 CT + RT (77.49%) | 74 CT + RT (79.57%) | |
| 27 RT alone (8.68%) | 4 RT alone (4.30%) | ||
| 5 CT alone (1.61%) | 4 CT alone (4.30%) | ||
| 38 no treatment (12.22%) | 11 no treatment (11.83%) | ||
| MRI characteristics | Pixel spacing (mm) mean (range) | 0.81 (0.46–1.09) | 0.90 (0.45–1.06) |
| Slice thickness (mm) mean (range) | 1.48 (1.00–2.00) | 1.41 (0.90–2.00) | |
| Spacing between slices (mm) mean (range) | 1.10 (0.50–2.00) | 1.36 (0.70–2.00) | |
| Number of slices mean (range) | 174 (80–360) | 150 (72–305) | |
| Volumetric parameters | Tumor volume (cm3) mean (range) | 33.14 (0.48–132.54) | 41.82 (2.47–116.12) |
| CE volume (cm3) mean (range) | 19.64 (0.44–90.06) | 24.90 (2.46–90.95) | |
| Necrotic volume (cm3) mean (range) | 13.50 (0.03–89.31) | 16.92 (0.00–69.20) | |
| CE rim width (cm) mean (range) | 0.57 (0.22–1.65) | 0.63 (0.24–1.25) | |
| Maximum diameter (cm) mean (range) | 5.11 (1.30–11.09) | 5.71 (2.55–9.80) | |
| Total surface (cm2) mean (range) | 67.27 (3.00–226.32) | 83.13 (13.27–196.04) | |
| Surface regularity mean (range) | 0.62 (0.24–0.99) | 0.57 (0.30–0.83) | |