Fig. 3.

Steady state and mGluR-stimulated de novo proteomes differ in Fmr1 knockout mice. a Venn diagram of proteins measured in steady state, wild-type (WT) DHPG and Fmr1 knockout (KO) DHPG BONLAC experiments. We noted that despite many proteins measured in common, there is limited overlap in proteins being made, suggesting distinct de novo proteomic responses at steady state and in response to DHPG treatment. b Pie charts of the top 50 FMRP targets from HITS-CLIP²⁴ and the consistently changed proteins in steady state, WT DHPG and FXS DHPG BONLAC studies. c Pie charts of top ASD genes and the BONLAC experiments (source of gene lists are in Supplementary Data 5)