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. 2017 Jan;65:724–733. doi: 10.1016/j.jmbbm.2016.09.004

Fig. 5.

Fig. 5

Decoupling losses of mechanical properties due to effects of TFV release and polymer degradation. (a) TFV cumulative release curves for 20PCL/80PLGA fibers loaded with 15, 30, and 40 wt% of TFV. Release profiles switched from a sustained release (15 wt% TFV) to a burst release at higher drug loading (30 and 40 wt% TFV). (b) Average Young׳s modulus of 20PCL/80PLGA fibers with and without TFV loading after in the release media for 1, 48, and 240 h. The loss of Young׳s modulus at early time point is associated with release of TFV. At prolonged time point, drug-load fibers exhibit a similar Young׳s modulus as the blank fibers. (c) Average tensile strength of 20PCL/80PLGA fibers with and without TFV loading after in the release media for 1, 48, and 240 h. A similar trend of losses in tensile strength can be seen for the blank and drug-loaded fibers.