Fig. 3.

Enrichment of human fecal microbial species in different mouse genotypes. a Species diversity (Shannon’s diversity index) of human fecal microbes established in NSG ABT and C57BL6/J ABT mice. b Human fecal microbial species enriched in NSG ABT versus C57BL6/J ABT mice. Linear Discriminant Analysis score were shown for taxa showing significant enrichment (p < 0.05 and |LDA| > 2) when all samples were treated as independent. Additionally, the significance of enrichment were also shown with different sample pooling strategies: “average across time points”—samples representing time points of a same mouse were combined, “average across time points and co-caged mice”—samples representing time points of all mice in a same cage were combined. LDA linear discriminant analysis