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. 2019 Feb 27;120(7):714–727. doi: 10.1038/s41416-019-0409-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Assessment of the reporting quality of the studies included in the meta-analysis. The reporting of the following parameters was evaluated: Study cohort, (1) number of patients, (2) tumour size/stage, (3) chemotherapy/radiation of tissue prior to surgery; Immunohistochemical staining, (1) antibody clone/product number, (2) immunohistochemistry procedures, (3) positive and negative controls; scoring (1) number of observers, (2) clear scoring criteria, (3) inter/intra-observer variability; Analysis and presentation of the results, (1) survival endpoint analysed, (2) direction of effect on survival in Kaplan–Meier plot, (3) estimated effects with confidence intervals for the marker and, at least for the final model, all other variables in the model