Fig. 5.

NSAIDs, exisulind and nicotinamide treatments, but not ketoprofen decrease tissue proliferation in vivo. Five females repTOPmitoIRE mice/group were treated with nimesulide (Nim), nicotinamide (Nam) or vehicle (DMSO) following an identical protocol described in Fig. 4 and Figure S4B. Pictures show the bioluminescence emission marking the proliferative activity in the repTOPmitoIRE reporter mouse (a) or in the dissected mammary glands (b). Data from more NSAIDs are shown in Fig. S5A. c Quantification of the photon emission as a measure of tissue proliferation from the dissected mammary glands; bars are the average ± SEM values of the photon emission normalised over the area of the acquisition surface (p/s/cm²/sr). *P < 0.05 mammary glands treated with DMBA and 15 mg/Kg nimesulide (Nim) or nicotinamide (Nam) versus DMSO treated animals; P-values were calculated by Student’s t-test