Table 2.
Bivariate logistic regression and multivariate logistic regression analysis of demographics and testing experience with carrier testing included as a PGTa
| Variable | Had PGT n (%) |
Not had PGT n (%) |
Unadjusted odds ratio [95% CI] |
P value | Adjusted odds ratio [95% CI] |
P value |
|---|---|---|---|---|---|---|
| Age b | ||||||
| 50+ | 222 (20.7) | 851 (79.3) | ref. | |||
| 25–49 | 140 (14.8) | 808 (85.2) | 0.7 [0.5–0.8] | <0.001 | ||
| 18–24 | 11 (3.3) | 320 (96.7) | 0.1 [0.07–0.5] | 0.001 | ||
| Age | ||||||
| 18–49 | 151 (11.8) | 1128 (88.2) | ref. | |||
| 50+ | 222 (20.7) | 851 (79.3) | 1.9 [1.2–2.0] | <0.001 | 2.2 [1.7–2.9] | <0.001 |
| Sex | ||||||
| Male | 85 (12.2) | 610 (87.8) | ref. | |||
| Female | 287 (17.5) | 1357 (82.5) | 1.5 [1.2–2.0] | 0.002 | 1.6 [1.2–2.1] | 0.001 |
| SEIFA (IRSAD) | ||||||
| First to fourth quintiles | 212 (14.7) | 1235 (85.3) | ||||
| Fifth quintile | 161 (18.1) | 730 (81.9) | 1.3 [1.0–1.6] | 0.03 | 1.2 [0.9–1.5] | 0.1 |
| Education | ||||||
| Never studied at university | 115 (11.9) | 863 (88.2) | ref. | |||
| Currently studying/completed university | 256 (18.7) | 1 115 (83.0) | 1.7 [1.4–2.2] | <0.001 | 2.3 [1.8–3.1] | <0.001 |
| Working in genomics and/or life sciences | ||||||
| No | 333 (15.0) | 1881 (85.0) | ref. | |||
| Yes | 40 (18.6) | 98 (81.4) | 2.3 [1.6–3.4] | <0.001 | 2.6 [1.7–3.1] | <0.001 |
| Parent c | ||||||
| Yes/No, I’m currently pregnant | 273 (19.9) | 1097 (80.1) | ref. | |||
| No | 100 (10.2) | 882 (89.8) | 0.5 [0.4–0.6] | <0.001 | 0.5 [0.4–0.7] | <0.001 |
| Adopted c | ||||||
| No/I don’t know | 358 (15.7) | 1926 (84.3) | ref. | |||
| Yes | 13 (24.5) | 40 (75.5) | 1.7 [0.9–3.3] | 0.09 | ||
| Genetic condition in self | ||||||
| No | 281 (13.5) | 1804 (86.5) | ref. | |||
| Yes | 92 (34.5) | 175 (65.5) | 3.4 [2.5–4.5] | <0.001 | 2.9 [2.1–4.1] | <0.001 |
| Genetic condition in family | ||||||
| No | 252 (13.6) | 1601 (86.4) | ref. | |||
| Yes | 121 (24.2) | 378 (75.8) | 2.0 [1.6–2.6] | <0.001 | 1.3 [1.0–1.7] | 0.09 |
| Self-reported health | ||||||
| Fair/poor/unknown | 66 (16.2) | 341 (83.8) | ref. | |||
| Excellent/very good/good | 307 (15.8) | 1 638 (84.2) | 1.0 [0.7–1.3] | 0.8 | ||
aCarrier tests were classified as PGT when:
(1) There was NO diagnosed genetic condition in themselves
(2) There was NO diagnosed genetic condition in their family
(3) When asked about why they had carrier testing, they indicated one or more of the following reasons:
a. I was planning to have children and wanted to know if there is a risk of passing on a genetic condition to my children
b. I wanted this information for my grandchildren
c. I thought I was at a higher risk because of my ethnic background
d. I was curious
e. I didn’t think about it, I just did it
bAge categories are structured to reflect the focus group categories from stage one of the Genioz research study
cThese questions were optional in the survey