Fig. 1.

Effects of future binge-drinking status and family history density (FHD) on fractional anisotropy (FA). a Regions where future binge-drinking status (orange), FHD (blue) or both (green) were associated with altered FA. b In the posterior limb of the internal capsule and cerebellar peduncle, future binge-drinking status was associated with persistently greater FA with age. c In the superior frontal gyrus, greater FHD was associated with reduced FA in early-adolescence, but not late-adolescence. d In a smaller region of the cerebellar peduncle, future binge-drinking status was associated with persistently greater FA, and FHD was associated with reduced FA in early-adolescence but not late-adolescence. e In the splenium of the corpus callosum, early in adolescence, future binge-drinking status was associated with greater FA, while greater FHD was associated with reduced FA, effects that both dissipated by late-adolescence