Table 2.

Anatomical location of all significant clusters identified in voxel-wise analysis

	Peak voxel			Peak	Volume (voxels)
Anatomical location	x	y	z	X 2
Fractional anisotropy
FA ~ Age + FHD + BINGE
Right posterior limb of the internal capsule	−3	20	−20	35.111	3022
Left posterior limb of the internal capsule	7	14	−15	27.564	2593
Left cerebellar peduncle	31	45	−37	22.221	602
FA ~ Age × FHD + BINGE
Left superior frontal gyrus	20	−32	31	23.258	540
Left cerebellar peduncle	14	39	−30	13.587a	98
FA ~ Age × FHD × BINGE
Splenium of the corpus callosum	14	41	15	31.606	948
Mean diffusivity
MD ~ Age + FHD + BINGE
Right superior corona radiata	−23	23	22	21.109	2022
Right posterior limb of the internal capsule	−9	8	8	21.521	776
MD ~ Age × FHD + BINGE
Right thalamus	−19	18	10	20.150b	274
Right thalamus	−10	11	13	19.879b	69
MD ~ Age × BINGE + FHD
Right superior frontal gyrus	−16	11	48	15.170c	457
Right precentral gyrus	−32	12	49	12.511c	205
Right precentral gyrus	−36	3	36	15.844c	168
Right superior longitudinal fasciculus	−35	17	37	10.990c	121
MD ~ Age × FHD × BINGE
Right superior frontal gyrus	−17	−51	8	40.966	1019

FHD family history density, MD mean diffusivity, FA fractional anisotropy

Peak X² and volume are reported for each cluster in relation to the linear growth (age-only) model, except as noted:

^aCompared to FA main-effects model in a mask containing significant voxels from both models (747 voxels)

^bCompared to MD main-effects model in a mask containing significant voxels from both models (1464 voxels)

^cCompared to MD main-effects model in a mask containing significant voxels from both models (3708 voxels)