Fig. 2.

Higher MT2 were found in OHSS patients and melatonin mediates AROM, VEGF and iNOS expression. Granulosa cells were collected from the OHSS patients and the non-OHSS patients. (a):MT2 mRNA expression was significantly higher in the OHSS group (p = 0.0459). (b):MT2 protein expression was significantly higher in the OHSS group. Granulosa cells of non-OHSS patients were treated with 0.005, 0.05 and 0.5 mmol/L of melatonin for 24 h. (c): melatonin of 0.5 mmol/L up-regulated AROM mRNA expression (p < 0.0063). (d): melatonin of 0.5 mmol/L up-regulated VEGF mRNA expression (p = 0.0219). (e): melatonin of 0.5 mmol/L down-regulated iNOS mRNA expression (p = 0.0037)