Fig. 2.

AC187 increases short-term alcohol intake, but does not affect food intake in outbred rats. Single administration of AC187 (250 μg/kg) did not affect a alcohol intake in outbred rats (N = 9) compared to vehicle (Veh) (N = 9) at the time point of 1 h, but significantly increased alcohol consumption at the time point of 4 h. There was no difference in long-term alcohol intake 24 h after AC187 administration. AC187 did not have an effect on b alcohol preference scores at any time point of 1 h, 4 h, or 24 h. No effect was noted on c water intake at any measured time of 1 h, 4 h, or 24 h, similarly to d total fluid intake scores for 1, 4, and 24 h, respectively. AC187 did not affect e food intake at the time point of 1 h, 4 h, or 24 h. (Data are presented as mean ± SEM; *P < 0.05, n.s.: P > 0.05)