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. 2019 Jan 23;44(6):1093–1102. doi: 10.1038/s41386-019-0323-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — sCT prevents ADE in outbred rats. A single injection of sCT (5 μg/kg) prevents the alcohol deprivation effect (ADE) in rats (N = 18) abstained from alcohol for 10 days. There was an increase in alcohol intake post abstinence in the vehicle (Veh) group, but not in the sCT group when compared to baseline values. (Data are presented as mean ± SEM; ***P < 0.001 for baseline vs sCT within the Veh group, ^#P < 0.05 for ADE vs ADE between the Veh-sCT groups, n.s.: P > 0.05)