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. 2019 Jan 23;44(6):1093–1102. doi: 10.1038/s41386-019-0323-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — sCT administration decreases lever-responding for alcohol and amount of self-administered alcohol in sP rats. a Acute sCT administration in the dose of 1 μg/kg (sCT1) (N = 12) and 5 μg/kg (sCT5) (N = 12) decreased the number of lever-responses for alcohol in a dose-response manner when compared to vehicle (Veh) (N = 12) in Sardinian alcohol-preferring (sP) rats exposed to the FR4 schedule of reinforcement. b Acute administration of sCT in the same doses reduced the amount of self-administered alcohol in a dose-response manner. c In the same experiment, body weight change (in grams) was increased by acute administration of sCT in two doses in a dose response-like effect. (Data are presented as mean ± SEM;⁺P < 0.05,⁺⁺P < 0.01 for Veh vs sCT1, ****P < 0.0001 for Veh vs sCT5 and ^###P < 0.001, ^####P < 0.0001 for sCT1 vs sCT5)