Fig. 4.

Pharmacological induction of PDK4 attenuates chemotherapy-induced cytotoxicity. a, b WST-1 assays revealing that the viability of murine hepatocytes (AML12 cells) exposed to 5-FU (500 µM) (a) or Ox (100 µM) (b) is significantly enhanced by simultaneous treatment with fenofibrate (50 or 200 µM). c, d WST-1 assays revealing that the viability of human colon cancer cells (HCT 116) exposed to 5-FU (500 µM) (c) or Ox (100 µM) (d) is significantly enhanced by simultaneous treatment with fenofibrate (50 or 200 µM). Each graph in (a–d) represents pooled data from three independent experiments. **P < 0.01; ***P < 0.001; n = 3.