Table 1.
Patients’ characteristics according to CD8 and PD-L1 expression
| Variables | Group | n | CD8 | PD-L1 | |||
|---|---|---|---|---|---|---|---|
| Mean ± SD, cells/mm2 | p | Negative n = 101 |
Positive n = 35 |
p | |||
| Gender | Male | 116 | 758 ± 703 | 0.961 | 81 (80.2) | 35 (100) | 0.004 |
| Female | 20 | 715 ± 676 | 20 (19.8) | 0 (0) | |||
| Age (years) | <65 | 59 | 723 ± 724 | 0.615 | 45 (44.6) | 56 (55.4) | 0.639 |
| ≥65 | 77 | 774 ± 679 | 14 (40.0) | 21 (60.0) | |||
| Smoking | Never smoker | 46 | 705 ± 632 | 0.786 | 34 (33.7) | 12 (34.3) | 0.947 |
| Smoker/ex-smoker | 90 | 776 ± 730 | 67 (66.3) | 23 (65.7) | |||
| Histology | SqCC | 90 | 755 ± 752 | 0.198 | 60 (59.4) | 30 (85.7) | 0.005 |
| Non-SqCCa | 46 | 746 ± 580 | 41 (40.6) | 5 (14.3) | |||
| ECOG PS | 0 | 103 | 735 ± 673 | 0.767 | 74 (73.3) | 29 (82.9) | 0.254 |
| 1 | 33 | 803 ± 774 | 27 (26.7) | 6 (17.1) | |||
| Surgery | Lobectomy and othersb | 121 | 779 ± 674 | 0.011 | 89 (88.1) | 32 (91.4) | 0.759 |
| Pneumonectomy | 15 | 533 ± 854 | 12 (11.9) | 3 (8.6) | |||
| TNM stage | I | 76 | 729 ± 595 | 0.068 | 56 (55.5) | 20 (57.1) | 0.750 |
| II | 48 | 826 ± 770 | 37 (36.6) | 11 (31.4) | |||
| III | 12 | 601 ± 980 | 8 (7.9) | 4 (11.4) | |||
| Adjuvant treatment | No treatment | 98 | 779 ± 728 | 0.536 | 72 (71.3) | 26 (74.3) | 0.706 |
| Chemotherapy | 16 | 717 ± 610 | 11 (10.9) | 5 (14.3) | |||
| Concurrent chemoradiotherapy | 15 | 571 ± 626 | 13 (12.9) | 2 (5.7) | |||
| Radiotherapy | 7 | 839 ± 634 | 5 (5.0) | 2 (5.7) | |||
| Relapse pattern | Local | 29 | 620 ± 663 | 0.760 | 21 (61.8) | 8 (57.1) | 0.766 |
| Distant | 19 | 779 ± 985 | 13 (38.2) | 6 (42.9) | |||
Values are presented as number (%) for PD-L1
SqCC squamous cell carcinoma, Non-SqCC non-squamous cell carcinoma, ECOG PS Eastern Cooperative Oncology Group performance status
aIncluding adenocarcinoma, large cell carcinoma, bronchoalveolar carcinoma, and non-small cell carcinoma
bBilobectomy (n = 1) and sleeve operation (n = 1)