Fig. 1.

Systemic administration of U50,488 increases while nor-BNI decreases binge-like alcohol consumption. a Mice received injection (ip.) of vehicle (saline) (N = 13) or U50,488 (5 mg/kg) (N = 14) 30 min prior to the start of the 4-hr test drinking session of the DID procedure. U50,488 treatment significantly increased alcohol consumption at both 2-hr and 4-hr time points (***p < 0.001). b Increased drinking following U50,488 treatment resulted in a trend for elevated blood alcohol concentrations (p = 0.056). c Mice received injection (ip.) of vehicle (saline) (N = 10) or nor-BNI (10 mg/kg) (N = 10) 2 h after the Day 3 session (22 hr prior to the start of the 4 hr (Day-4) test drinking session of the DID procedure). Nor-BNI treatment significantly decreased alcohol consumption at both 2 hr and 4 hr time points (**p < 0.01). d Decreased drinking following nor-BNI treatment resulted in a significant reduction in blood alcohol concentrations (*p < 0.05)