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. 2018 Dec 11;44(6):1084–1092. doi: 10.1038/s41386-018-0294-3

Fig. 5.

Fig. 5

Chemogenetic inactivation of DYN-containing neurons in CeA reduces binge-like alcohol drinking. a In mice treated with a virus containing an inhibitory (hM4Di) DREADD in the CeA (N = 7), CNO (3 mg/kg) injection significantly reduced alcohol consumption at 2-hr and 4-hr time points compared to saline injection (***p < 0.001). b In mice treated with a control virus in the CeA (N = 7), neither CNO (3 mg/kg) nor saline injection significantly altered alcohol intake at 2-hr and 4-hr time points. c In mice harboring an inhibitory (hM4Di) DREADD in the CeA, systemic administration of the KOR agonist U50,488 (5 mg/kg) reversed the decrease in alcohol consumption at 2-hr and 4-hr time points following CNO (3 mg/kg) injection (***p < 0.001). d Representative viral expression in the CeA (mCherry tag visualized by colorimetric (DAB) staining)