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. 2019 Feb 22;120(5):488–498. doi: 10.1038/s41416-018-0374-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — FZD2, FZD8, and CSNK1A1, WNT signal pathway genes, were dysregulated by para-BI6015-treated gastric cancer (GC) cancer cell lines, but divergently influenced patient survival, assessed using a TCGA STAD Asian dataset. The total available number of samples that had survival information and mRNA expression levels in a TCGA STAD dataset was 368. We calculated the 1st quantile and the 3rd quantile of gene expression levels. By using these quantiles for dividing Asian samples (n = 77) in the TCGA dataset into two groups, and upper 25% and bottom 25% group (see details in the “Survival analysis” section of the Methods). For FZD2, the number of samples in the bottom 25% group was 16 and that in upper 25% group was 23. For FZD8, the sample numbers in the upper 25% and bottom 25% groups were 24 and 20, respectively. For CSNK1A1, the sample numbers in the upper 25% and bottom 25% groups were 22 and 14, respectively. “+” marks show censored patients. P values of survival analysis were derived by the log-rank test