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. 2018 Dec 5;13(4):921–936. doi: 10.1038/s41396-018-0323-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Relative abundance distribution of ASVs used as bioindicators in the different treatments (Controls, pBMC, pBMC + VC and VC) per sample. The size of the circles represent the relative abundances. We added colors to ASV relative abundances belonging to the same treatments. Class and genus of each ASVs are also shown in this figure. We grouped the ASVs in 5 different groups depending on how the different ASVs showed statistic differences (P < 0.5) in a False Discovery Rate test performed after a two way ANOVA using inoculation of pBMC and VC as factors. (G1) Statistically significant ASVs (P < 0.05) in the interaction pBMC:VC. (G2) Statistically significant ASVs (P < 0.05) in the interaction pBMC * (VC * pBMC:VC). (G3) Statistically significant ASVs (P < 0.05) in the interaction pBMC:VC * VC. (G4) Statistically significant ASVs (P < 0.05) in the interaction pBMC:VC * (VC * pBMC). (G5) Statistically significant ASVs (P < 0.05) in the interaction VC * (pBMC * pBMC:VC)