Table 2.

Association of clinical and pathologic factors with HER2 status: univariate and multivariate analyses

	Development cohort
	Univariate		Multivariate
	OR (95%CI)	P-value	OR (95%CI)	P-value
Gender
Female	1		–	–
Male	0.60 (0.34–1.06)	0.076	–
Type of material
Surgical sample	1		1
<6 biopsies	1.71 (0.96–3.05)	0.063	1.93 (0.91–4.11)	0.069
≥6 biopsies	2.47 (0.97–6.32)	0.058	2.29 (0.64–8.22)	0.201
Site of sampling
Primary tumour	1		1
Metastases	1.80 (1.03–4.15)	0.042	4.12 (1.11–15.2)	0.034
Tumour location
Body	1		–
O–G junction	1.88 (1.08–3.26)	0.023	–	–
Fundus	1.01 (0.28–3.59)	0.658	–	–
Histotype
Intestinal	1		1
Diffuse	0.23 (0.12–0.44)	<0.0001	0.41 (0.17–0.98)	0.045
Tumour grading
G1 versus G2 versus G3	0.05 (0.02–0.16)	<0.0001	0.09 (0.02–0.41)	0.0018

OR (95%CI) odds ratio (95% confidence interval), O–G junction oesophago-gastric junction