Fig. 10.

CZ-7 triggered the activation of Nrf2 and its target genes. a, b Representative immunoblots and densitometry analysis of Nrf2 in the nuclear/cytosolic relative fold and in the total protein of hippocampus. c, d Representative immunoblots and densitometry analysis of NQO1 and HO-1 in the total protein of hippocampus. Values are expressed as mean ± SEM. n = 4 for each group. ^###P < 0.001 vs. Sham group. *P < 0.05, **P < 0.01 vs. Model group. For Nrf2 in the nuclear/cytosolic relative fold, one-way ANOVA, F (5, 18) = 2.540, P = 0.0659. For Nrf2 in the total protein, one-way ANOVA, F (5, 22) = 12.46, P < 0.0001. For NQO1, one-way ANOVA, F (5, 22) = 7.909, P = 0.0005. For HO-1, one-way ANOVA, F (5, 23) = 10.73, P < 0.0001